 | Gunner Kill 100 Enemies while using the Minigun. |
 | Breaker Kill 100 Enemies while using the Hailstorm. |
 | Heavy Operator Kill 400 Enemies while using the Minigun. |
 | Conjurer Kill 100 Enemies while using the Dragon's Grasp. |
 | Practitioner Complete Chapter 1 on any difficulty. |
 | Aversion Therapy Complete a level on any difficulty without dying. |
 | Hallucinations |
 | Freezer Kill 400 Enemies while using the Hailstorm. |
 | Shocker Kill 100 Enemies while using Shock Therapy. |
 | Lighter Kill 100 Enemies while using the Sunbeam. |
 | Suicidal Tendencies |
 | Operative Complete Chapter 2 on any difficulty. |
 | Xenophobia Kill 10 or more enemies at the same time with any weapon. |
 | Bomber Kill 100 Enemies while using the Dream Cleaner. |
 | Wisdom Find and enter in all of the Secret areas in any one level of the game. |
 | Paladin Kill 400 Enemies while using the Sunbeam. |
 | Focused Mind Defeat a Doorkeeper without taking any damage. |
 | OCD Use every weapon at least once in any level of the game in Story mode. |
 | Specialist Complete Chapter 3 on any difficulty. |
 | Stormer Kill 400 Enemies while using Shock Therapy. |
 | Master Complete Chapter 4 on any difficulty. |
 | Manic Episode Enter Berserker Rage at least once in each level of the game in Story mode. |
 | Draconist Kill 400 Enemies while using the Dragon's Grasp. |
 | Technician Kill 400 Enemies while using the Dream Cleaner. |
 | Poor Sleeper Complete Story mode on the Bad Dream difficulty. |
 | Psychoanalysis Kill 25 opponents in any Multiplayer game mode. |
 | Dreamkiller Defeat a Dreamkiller without taking any damage. |
 | Dissociative Disorder |
 | Somnambulist Complete Story mode on the Nightmare difficulty. |
 | Delusions of Grandeur Finish a Deathmatch game with the highest score (with at least 3 other players involved). |
 | Instinctual Action Enter Berserker Rage during a Multiplayer game. |
 | Untouchable Kill 10 opponents in a row without dying in a Multiplayer game. |
 | Pagophobia Complete one level in Story mode while only using the Hailstorm. |
 | Hoplophobia Complete one level in Story mode while only using the Minigun. |
 | Mastermind Conquer 50 brains in Conquest mode. |
 | Mind Guard Return your team's flag at least 5 times in one CTF match. |
 | Opiophobia Complete one level without receiving any Health pickups. |
 | Astraphobia Complete one level in Story mode while only using Shock Therapy. |
 | Latent Abilities Complete every level on any difficulty without dying in the Subconscious. |
 | Absolute Threshold Achieve the Gold weapon upgrade rank on the Insanity difficulty. |
 | Heliophobia Complete one level in Story mode while only using the Sunbeam. |
 | Rhabdophobia Complete one level in Story mode while only using the Dragon's Grasp. |
 | Prescription Kill 100 opponents in any Multiplayer game mode. |
 | Latent Abilities Complete every level on any difficulty without dying in the Subconscious. |
 | Immortal Complete every level on any difficulty without dying. |
 | Ligyrophobia Complete one level in Story mode while only using the Dream Cleaner. |
 | Heliophobia Complete one level in Story mode while only using the Sunbeam. |
 | Free Association Kill 3 or more opponents at the same time in a Multiplayer game. |
 | Psycho Logical Complete a Single Player game in Time Trial mode. |
 | Simple Jack Complete a Single Player game in Single Weapon mode. |
 | Treatment Kill 300 opponents in any Multiplayer game mode. |
 | Free Association Kill 3 or more opponents at the same time in a Multiplayer game. |
 | Psycho Logical Complete a Single Player game in Time Trial mode. |
 | Treatment Kill 300 opponents in any Multiplayer game mode. |
 | Ligyrophobia Complete one level in Story mode while only using the Dream Cleaner. |
 | Simple Jack Complete a Single Player game in Single Weapon mode. |
 | Lucid Guardian Complete Story mode on the Insanity difficulty. |