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| Box as Chuck Zito | 100% | |
| Enter "ZITO" as a name in career mode to unlock Chuck Zito. | ||
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| Illegal elbow | 100% | |
| During a match, hold R1 + R2 and press Square. | ||
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| Box as David DeMartini | 100% | |
| Enter "DEMART" as a name in career mode to unlock David DeMartini. | ||
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| Illegal kidney punch | 100% | |
| During a match, hold R1 + R2 and press Circle. | ||
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| Box as Joe Mesi | 100% | |
| Enter "BAILEY" as a name in career mode to unlock Joe Mesi. | ||
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| Box as Ray Austin | 100% | |
| Enter "AUSTIN" as a name in career mode to unlock Ray Austin. | ||
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| Box as John Botti | 100% | |
| Enter "JBOTTI" as a name in career mode to unlock John Botti. | ||
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| Box as Owen Nolan | 100% | |
| Enter "OWNOLAN" as a name in career mode to unlock Owen Nolan. | ||
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| Box as Trevor Nelson | 100% | |
| Enter "NELSON" as a name in career mode to unlock Trevor Nelson. | ||
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| Illegal low punch | 100% | |
| During a match, hold R1 + R2 and press X. | ||
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| Bite opponent's ear | 100% | |
| During a match, hold L1 + R1 and press Triangle + Circle + X + Square. | ||
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| Box as David Bostice | 100% | |
| Enter "BOSTICE" as a name in career mode to unlock David Bostice. | ||
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| Illegal head butt | 100% | |
| During a match, hold R1 + R2 and press Triangle. | ||
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| Box as Bernando Osuna | 100% | |
| Enter "OSUNA" as a name in career mode to unlock Bernando Osuna. | ||
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| Illegal kick | 100% | |
| During a match, press Triangle + Circle + X + Square. | ||
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| Box as Ashy Knucks | 100% | |
| Enter "MECCA" as a name in career mode to unlock Ashy Knucks. | ||
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| Box as Charles Hatcher | 100% | |
| Enter "HATCHER" as a name in career mode to unlock Charles Hatcher. | ||
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| Signature moves | 100% | |
| Press Triangle + Circle to do a boxer's signature move. For example, press Triangle + Circle with Tua and he will do his devastating left hook. | ||
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| Box as David Defiagbon | 100% | |
| Enter "DEFIAGBN" as a name in career mode to unlock David Defiagbon. | ||
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| Box as Barry Sanders | 100% | |
| Enter "MRBARRY" as a name in career mode to unlock Barry Sanders. | ||
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| Box as Steve Francis | 100% | |
| Enter "STEVEF" as a name in career mode to unlock Steve Francis. | ||
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| Box as Junior Seau | 100% | |
| Enter "JRSEAU" as a name in career mode to unlock Junior Seau. | ||
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| Box as Jason Giambi | 100% | |
| Enter "JGIAMBI" as a name in career mode to unlock Jason Giambi. | ||
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Taking full advantage of the Playstation 2 console, Knockout Kings 2001 delivers unbelievably true-to-life graphics with up to 10,000 polygons per boxer. Many of the game’s champions have stepped into a CyberScanning machine to create perfect body and head replications, delivering the most realistic looking boxers ever seen. Add in the world’s top female boxers, and Knockout Kings 2001 steps into the ring and lands a first-round knockout punch. 
