Rampage: Total Destruction for the Wii™, will allow players to choose from 40 unlockable monsters, and seven international cities, including Chicago, Hong Kong and London. Players will start with six characters available, including the original terror trio of George, Lizzie and Ralph, and graduate to new crazy monsters hidden throughout the various 3D city environments, such as Sarah the Spider, Plucky the Chicken and Fifi the Rabid French Poodle.

Virtually everything in the Rampage: Total Destruction environments can be damaged, broken, and utterly destroyed with plenty of hilarious results. Aided by power–ups, all monsters are capable of acquiring a number of upgrades throughout the course of a single campaign. Rampage: Total Destruction allows multiple players to compete or cooperate as they battle through the game.