Little Gamers is a 2D action side-scroller that borrows many gameplay elements from action games such as Metal Slugs and Madness Interactive, and mixes them with the webcomic feel and humor of the webcomic "Little Gamers" to create a unique, cute, but deadly combination. During his travels all around the world in 16 action-packed levels (only five in the demo), Mr. Madsen, the main protagonist, faces many enemies such as hippies, zombies, pirates, and ninjas.