Guybrush's adventures continue on the high seas as pox-plagued pirates lay siege to the innocent Mer-People. Between defending the Mer-People and dodging the persistent pirate hunter hot on his trail, Guybrush manages to catch up to his beloved wife and despised arch-nemesis, but the reunion is short-lived. Now Guybrush must focus on eradicating the Pox of LeChuck before more harm can be done. And as the Mighty Pirate draws closer to a cure, the waters will only grow murkier in this thrilling chapter of the epic saga.