You can't "kill" him, but to win the fight, this is what I do: first grab a "normal" weapon, like the Nitro launcher or N90, then, when he shoots blue "shadows",
shoot at him while running in circles.
(r2 to strafe)
then, he'll jump to another point, get out of reach of the red beams he shoots and grab you Splitter Riffle.
shoot at him for a couple of times, when the cutscene doesn't appear, he's not weak enough yet, continue evading the attacks and shooting.
when the cutscene DOES appear, Neffarious will fly away, for the fast way, shoot the big robot guy with your Splitter, the first line of little robots with your Multi Disc Gun.
then fly trough with charge boots.
try evading all robots and you will be in a second arena.
Nefarious is in the sky, when his light gets blue, he'll shoot a blue beam at you, that follows you.
hide behind a rock and keep watching Nefarious.
when it's red, he'll throw rockets.
if you get to the middle of the arena, he'll come down,
throwing blue balls that cause shockwaves over the ground.
jump on top of a rock and shoot Nefarious with your weapons.
when he spins around with red beams, Splitter him again.
soon, he'll fall and you get a cutscene.
if you find it hard evading attacks, use a Tesla barier or Shield Charger.
Q:What is the insomniac museum and what can you do there?
A1:
A special planet in the game, all sort of Insomniac things are there, for instance, you can ride a turboslider
(car like thing) trough a florana level, and you can see
how some enemies were made -Answer by:Quartoch
Q:How do you go to the secret are in the starship phoenix trofy room right next to it that when you hit the door sasha says yuo dont have acess YET!?
A1:
You have to get all trophies first
A2:
You need all trophys to enter in there if you have collected all trophys the door opens and will you teleport to insomniac museum -Answer by:gamefreak1
Question from: Guest
Rating: 67%
Was this QA for Ratchet And Clank: Up Your Arsenal :
Q:To get a saber pause the game then press circle square circle square up down left left
Qwark in a tu tu during any vid comic press up up down down left right circle square square?
A1:
Thats right you will also find out big al sez it in the game -Answer by:jordan12234
Question from: Guest
Rating: 63%
Was this QA for Ratchet And Clank: Up Your Arsenal :
Go to the mission where the arena is and go do the races as a mission cause that is a mission on that planet then beat all the race challenges not the fighting challenges and ull get the boots -Answer by:cheatmaster234
A2:
To get the charge boots go to planet daxx do"nt get over the first hypershot target alone go to left then jump you will see there floranian blood flies(there is a skill point)and comes a very big bot use the nitro erupter.if you have killed him go again to left and fight .somewhere is a little station.hop up there and you have the charge boots! -Answer by:gamefreak1
Question from: Guest
Rating: 56%
Was this QA for Ratchet And Clank: Up Your Arsenal :
Lords of Legend RPG 
How do I get online on rachet and clank uya it keeps sayin no account when I set one up on the game?
Bogus
Helpful
PS2