Centipede: Infestation is a post-apocalyptic action experience that features run-n-gun shooting style gameplay with tower defense-style objects, paying homage to the original Centipede while bringing the brand into the 21st century. Players assume the role of an orphaned teenager hero named Max as he trudges through the wasteland, fighting off giant bugs. As Max travels he encounters a young teen named Maisy who possesses a collection of seeds that hold the secret to bringing plant life back to the wasteland. Max and Maisy join forces to grow these gardens and protect the last natural resources on earth.